The immunological similarity of rat glandular kallikreins
نویسندگان
چکیده
منابع مشابه
Biochemical, Pharmacological, and Functional Aspects of Glandular Kallikreins
Kallikrein (EC 3.4.21.8) specifies those serine proteinases which liberate kinins from kininogens by limited proteolysis and have no or only little proteolytic activity on other proteins (for review, see refs. 2,3,21). Unfortunately, this definition fits two totally different groups of proteinases: the glandular, tissue or organ kallikreins on the one hand, and the plasma or serum kallikrein on...
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Six chimeric constructs of the sequentially similar growth factor-associated kallikreins-epidermal growth factor binding protein (EGF-BP) and the gamma-subunit of nerve growth factor (gamma-NGF)--have been expressed, and their ability to generate complexes with epidermal growth factor (EGF) and beta-NGF, analogous to the high molecular weight forms (7S NGF and HMW-EGF) found in the mouse submax...
متن کاملExistence of prokallikrein in the kidney. Its biochemical properties compared to three active glandular kallikreins from the kidney, serum, and urine of the rat.
Prokallikrein in the kidney was partially purified with immunoaffinity and DEAE Sephadex A-50 column chromatographies, and its biochemical properties were studied in comparison to three active glandular kallikreins purified from kidney, serum, and urine of the rat. The properties of the enzyme obtained by trypsin activation of prokallikrein were identical with those of active glandular kallikre...
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Arthritis was produced in rats by the intravenous injection of Mycoplasma arthritidis. Metabolic inhibiting antibody and indirect hemagglutinating antibody could not be detected in the sera of arthritic or convalescent animals. Nonmurine species of mycoplasma were capable of inducing metabolic inhibiting antibody in the rat. A hypothesis based upon the possible occurrence of heterogenetic antig...
متن کاملKallikreins: unravelling the genetics of autoimmune glomerulonephritis.
Human disease gene discovery has entered a new era where genome-wide associations (GWA), and high throughput sequencing technologies are providing a first survey of the complex genetic architecture of common diseases. Immune-mediated glomerulonephritis, a shared pathological feature of systemic lupus erythematosus (SLE), systemic vasculitis and Goodpasture syndrome, displays a strong genetic co...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1977
ISSN: 0264-6021
DOI: 10.1042/bj1670835